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Image Search Results
Journal:
Article Title: Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV
doi:
Figure Lengend Snippet: Expression of high-affinity receptors on macrophages infected by HIV. Treatment of HIV-infected M/M with anti-NGF Ab (M/M + HIV + anti-NGF), but not with an IgG isotypic Ab (M/M + HIV + IgG), modifies the cellular expression of p140 trkA high-affinity receptor. Quantitative analysis of p140 trkA-immunoreactive cells carried out with a computerized image-analysis system (Zeiss Axiophot 2 microscope equipped with a Vidas Kontron system) shows that the increase of p140 trkA immunopositive cells in HIV-infected human M/M (M/M + HIV) was statistically significant (ANOVA: F(4, 85) = 116.017; P < 0.01) compared with mock-infected human M/M (M/M). Treatment of HIV-infected M/M with anti-NGF Ab (M/M + HIV + anti-NGF) yielded a statistically significant decrease (P < 0.01) of p140 trkA immunoreactivity in comparison to HIV-infected M/M (M/M + HIV), mock-infected human M/M (M/M + anti-NGF), or HIV-infected M/M with an irrelevant IgG Ab (M/M + HIV + IgG).
Article Snippet: Quantitative analysis of p140 trkA-immunoreactive cells was carried out on the number of p140 trkA- or p75 NTR -immunopositive cells out of 100 cells per six microscopic fields at ×40 magnification using a computerized image-analysis system (
Techniques: Expressing, Infection, Microscopy